Complex Regional Pain Syndrome – formerly known as Reflex Sympathetic Dystrophy – is a chronic, debilitating disease of the sympathetic nervous system that typically affects more women than men. The most troubling symptom of CRPS is its continuous, intense pain that mainly affects the arms, hands, legs, and feet. The symptoms of CRPS can be so severe they can interfere with your sleep, your job, your relationships, and even your mental health. The symptoms can drastically reduce your quality of life. Often, the condition results in long term disability.